|
Symbol Name ID |
Il21
interleukin 21 MGI:1890474 |
| Darker colors indicate more annotations |
| Human Phenotypes | Increased circulating IgE level |
Decreased circulating IgG level |
Decreased proportion of class-switched memory B cells |
Abnormal T cell count |
Leukopenia |
Pericarditis |
Lymphadenopathy |
Inflammation of the large intestine |
Crohn's disease |
Subacute progressive viral hepatitis |
Lupus nephritis |
Nephritis |
Abnormality of the immune system |
Discoid lupus rash |
Malar rash |
Serositis |
Decreased circulating complement C3 concentration |
Decreased circulating complement C4 concentration |
Antineutrophil antibody positivity |
Perinuclear antineutrophil antibody positivity |
Antinuclear antibody positivity |
Anti-dsDNA antibody positivity |
Anti-La/SS-B antibody positivity |
Anti-Sm antibody positivity |
Anti-U1 ribonucleoprotein antibody positivity |
Antiphospholipid antibody positivity |
Systemic lupus erythematosus |
Asthma |
Recurrent respiratory infections |
| Disease(s) Associated with IL21 | |||||||||||||||||||||||||||||
| asthma | |||||||||||||||||||||||||||||
| common variable immunodeficiency 11 | |||||||||||||||||||||||||||||
| hepatocellular carcinoma | |||||||||||||||||||||||||||||
| systemic lupus erythematosus |
| Mouse Phenotypes | abnormal class switch recombination |
abnormal T cell differentiation |
decreased germinal center B cell number |
decreased CD4-positive, alpha-beta T cell number |
abnormal CD4-positive, alpha beta T cell morphology |
abnormal gamma-delta T cell morphology |
abnormal spleen germinal center morphology |
decreased spleen germinal center number |
abnormal germinal center B cell physiology |
increased IgE level |
decreased IgG1 level |
abnormal CD4-positive, alpha-beta T cell physiology |
abnormal interleukin level |
decreased susceptibility to experimental autoimmune encephalomyelitis |
increased susceptibility to experimental autoimmune encephalomyelitis |
|
| Availability | Mouse Genotype | |||||||||||||||
| Il21tm1Lex/Il21tm1Lex | ||||||||||||||||
| Il21tm1Llit/Il21tm1Llit | ||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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